POST-TRAUMATIC STRESS DISORDER SYMPTOM SEVERITY, TRAUMA LOAD AND SLEEPING DIFFICULTIES IN TRAUMA-EXPOSED, TREATMENT-SEEKING ADOLESCENTS

Post-traumatic stress disorder symptom severity, trauma load and sleeping difficulties in trauma-exposed, treatment-seeking adolescents

Introduction: Sleep disturbances are associated with various anxiety- and trauma-related disorders, and specifically with post-traumatic stress disorder (PTSD).Two of the core symptoms of PTSD are recurrent distressing dreams about the traumatic event and difficulty in falling or staying asleep (insomnia).Sleep is essential for functioning, with po

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Therapeutic targeting of alternative splicing

Gene transcription leads to the generation of pre-mRNA molecules which contain both coding sequences (exons) and intervening non-coding sequences (introns).The primary transcript needs further processing which involves the excision of introns and ligation of exons.This process is called RNA splicing.Nearly all primary transcripts undergo alternativ

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